Six-eyed sand spider

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All Hexophthalma spiders produce venom with dermonecrotic effects, which means it can destroy skin and tissue. The damage is caused by proteins related to sphingomyelinase D, which are found in the venom of all sicariid spiders. For this species, the detailed effects on humans are unknown, because its venom has mainly been studied in the laboratory.1

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The spider is capable of a medically significant bite. Serious or even life-threatening wounds are possible, especially if the wound becomes infected or the venom spreads through the body. No bites from this spider in southern Africa have been proven, and contact with people is considered unlikely.1

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It relies on stillness and camouflage rather than running, and it can shift quickly across loose sand when disturbed.1